A nonparametric analysis of the Cournot model

An observer makes a number of observations of an industry producing a homogeneous good. Each observation consists of the market price, the output of individual firms and perhaps information on each firm's production cost. We provide various tests (typically, linear programs) with which the observer can determine if the data set is consistent with the hypothesis that firms in this industry are playing a Cournot game at each observation. When cost information is wholly or partially unavailable, these tests could potentially be used to derive cost information on the firms. This paper is a contribution to the literature that aims to characterize (in various contexts) the restrictions that a data set must satisfy for it to be consistent with Nash outcomes in a game. It is also inspired by the seminal result of Afriat (and the subsequent literature) which addresses similar issues in the context of consumer demand, though one important technical difference from most of these results is that the objective functions of firms in a Cournot game are not necessarily quasiconcave

A Nonparametric Analysis of the Cournot Model

An observer makes a number of observations of an industry producing a homogeneous good. Each observation consists of the market price, the output of individual rms and perhaps information on each rm's production cost. We provide various tests (typically, linear programs) with which the observer can determine if the data set is consistent with the hypothesis that rms in this industry are playing a Cournot game at each observation. When cost information is wholly or partially unavailable, these tests could potentially be used to derive cost information on the rms. This paper is a contribution to the literature that aims to characterize (in various contexts) the restrictions that a data set must satisfy for it to be consistent with Nash outcomes in a game. It is also inspired by the seminal result of Afriat (and the subsequent literature) which addresses similar issues in the context of consumer demand, though one important technical di erence from most of these results is that the objective functions of rms in a Cournot game are not necessarily quasiconcave. Keywords:

Genetic and Molecular Factors in Drug-Induced Liver Injury: A Review

The diagnosis of drug-induced liver injury (DILI) is challenging and based on complex diagnostic criteria. DILI falls into two main categories i) intrinsic 'dose-dependent' Type A reactions ii) 'idiosyncratic' or Type B reactions (which are usually not predictable). Idiosyncratic reactions can be immunoallergic (hypersensitivity), or metabolic, although overlap between categories can occur. The aim of this review is to summarise the general view of underlying mechanisms in DILI and to highlight individual risk factors for developing hepatotoxicity. Polymorphisms of bioactivation/ toxification pathways through CYP450 enzymes (Phase I), detoxification reactions (Phase II) and excretion/transport (Phase III) are explored together with immunological factors that might determine DILI. The importance of establishing a multidisciplinary and multi-centric network to promote the understanding and research in hepatotoxicity is underlined. Challenges such as genetic analyses for association studies and whole genome studies, pharmacogenetic testing and future approaches to study DILI are considered. Knowledge regarding these operational mechanisms could provide further insight for the prospective identification of susceptible patients at risk of developing drug-induced hepatotoxicity.

Phase diagram and magnetic properties of La1−x_{1-x}Cax_xMnO3_3 compound for 0≤x≤0.230\leq x \leq 0.23

In this article a detailed study of La$_{1-x}$Ca$_x$MnO$_3$ ($0\leq x \leq 0.23$) phase diagram using powder x-ray diffraction and magnetization measurements is presented. Unfortunately, in the related literature no properly characterized samples have been used, with consequence the smearing of the real physics in this complicated system. As the present results reveal, there are two families of samples. The first family concerns samples prepared in atmosphere ($P({\rm O}_2)=0.2$ Atm) which are all ferromagnetic with Curie temperature rising with $x$. The second family concerns samples, where a post annealing in nearly zero oxygen partial pressure is applied. These samples show a canted antiferromagnetic structure for $0\leq x \leq 0.1$ below $T_N$, while for $0.125\leq x <0.23$ an unconventional ferromagnetic insulated phase is present below $T_c$. The most important difference between nonstoichiometric and stoichiometric samples concerning the magnetic behavior, is the anisotropy in the exchange interactions, in the stoichiometric samples putting forward the idea that a new orbital ordered phase is responsible for the ferromagnetic insulating regime in the La$_{1-x}$Ca$_x$MnO$_3$ compound

Magnetic transitions in Pr2NiO4 single crystal

The magnetic properties of a stoichiometric Pr2NiO4 single crystal have been examined by means of the temperature dependence of the complex ac susceptibility and the isothermal magnetization in fields up to 200 kOe at T=4.2 K. Three separate phases have been identified and their anisotropic character has been analyzed. A collinear antiferromagnetic phase appears first between TN = 325 K and Tc1 = 115 K, where the Pr ions are polarized by an internal magnetic field. At Tc1 a first modification of the magnetic structure occurs in parallel with a structural phase transition (Bmab to P42/ncm). This magnetic transition has a first‐order character and involves both the out‐of‐plane and the in‐plane spin components (magnetic modes gx and gxcyfz, respectively). A second magnetic transition having also a first‐order character is also clearly identified at Tc2 = 90 K which corresponds to a spin reorientation process (gxcyfz to cxgyaz magnetic modes). It should be noted as well that the out‐of‐phase component of χac shows a peak around 30 K which reflects the coexistence of both magnetic configurations in a wide temperature interval. Finally, two field‐induced transitions have been observed at 4.2 K when the field is directed along the c axis. We propose that the high‐field anomaly arises from a metamagnetic transition of the weak ferromagnetic component, similarly to La2CuO4

Mimicry and mitonuclear discordance in nudibranchs : new insights from exon capture phylogenomics

Open access via the Wiley Jisc Agreement Funding Information Gorgon Barrow Island Net Conservation Benefits Fund The University of Western Australia Malacological Society of Australasia ACKNOWLEDGEMENTS We are grateful to our collaborators who have contributed specimens to this work, including David Mullins, Gary Cobb, Greg Rouse, Karen Cheney, Kate Dawson, Lisa Kirkendale, Terry Farr, and Terry Gosliner. We also thank Elizabeth Kools for coordinating K.K.S.L's tissue sampling at the California Academy of Sciences and for sending specimens for this work. We sincerely thank Alison Devault and Jakob Enk from Arbor Biosciences for logistical support and advice, and Greg Rouse, Joel Huey, and Josefin Stiller for feedback on data analysis. Funding for this project comes from the Gorgon Project's Barrow Island Net Conservation Benefits Fund, The University of Western Australia, and the Malacological Society of Australasia. K.K.S.L. was supported by a University Postgraduate Award for International Students (UPAIS) and an RTP International Fees Offset scholarship (RTPFI) administered by the University of Western Australia, as well as a postgraduate doctoral scholarship from the Natural Sciences and Engineering Research Council of Canada (NSERC). Here we provide permit details for newly collected specimens that do not derive from Layton et al. (2018). Specimens from Western Australia were collected under permits from the Department of Parks and Wildlife, including a regulation 17 licence to collect fauna for scientific purposes (SF010218, SF010710) and a regulation 4 exemption to collect marine invertebrates within Ningaloo Marine Park (CE005306). Specimens from Queensland were collected under permits from the Department of Agriculture, Fisheries and Forestry (Permit #: 183990). Specimens from Victoria were collected under permits from the Department of Environment, Land, Water and Planning (Permit #: 10007853). The specimen from California was collected under a permit from California Department of Fish and Wildlife (Permit #: 4564).Peer reviewedPublisher PD

TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres.

Shorter telomeres have been associated with increased risk of malignancy, including colorectal cancer (CRC). Telomere length is heritable and may be an intermediate phenotype linked to genetic susceptibility to CRC